You know you feel lousy when you haven’t gotten enough sleep, but
you probably didn’t know why—and neither did scientists. Although
anyone who’s pulled an all-nighter or stayed up with a screaming baby
or otherwise failed to get a good seven hours of shut-eye can testify
to how grumpy they are the next morning, exactly what, in the brain,
was behind that grumpiness was anyone’s guess. Now it can be told: your
prefrontal cortex has gotten disconnected from your amygdala.
So find scientists who kept 13 healthy volunteers up for 35 hours
straight, for one day and the following night and another day, and
compared them to 13 similar people who slept during that intervening
night. At the end of day two, all 26 had their brains scanned with
functional magnetic resonance imaging (fMRI), while they were shown 100
images that fell along an emotional gradient from neutral to very
upsetting, from images of leaves and wicker baskets to pictures of
mutilated bodies, severed limbs and children with grotesque tumors.
In the sleep-deprived, seeing gruesome images led to a noticeable
spike in activity in the brain’s amygdale, the structure that tags
incoming information with an emotion, especially a negative
one—labelling a sight or sound frightening or disgusting. On no sleep,
the scientists from the University of California, Berkeley, and Harvard
Medical School will report online tomorrow in the journal Current Biology, the amygdala goes into overdrive, and the usual braking mechanism is broken.
“It’s almost as though, without sleep, the brain had reverted back
to more primitive patterns of activity, in that it was unable to put
emotional experiences into context and produce controlled, appropriate
responses,” said Matthew Walker, director of Berkeley’s Sleep and
Neuroimaging Laboratory and lead author of the study.
Tracing the patterns of firing showed why. Usually, signals from the
amygdala reach the prefrontal cortex and vice versa. Since the
prefrontal cortex is the site of logical reasoning, it can take the
amygdala’s terror and calm it down by pointing out that, say, the
frightening sound coming from the ceiling is just branches blowing in
the wind, or that a terrifying scene in a movie is just celluloid.
In sleep-deprived brains, the fMRI showed, the amygdala connects
more strongly to the locus coeruleus. This evolutionarily-ancient part
of the brain, rather than acting as an emotional brake the way the
prefrontal cortex does, steps on the accelerator: it releases
noradrenalin, ramping up the brain’s jumpiness and emotionality even
further. “The emotional centers of the brain were over 60 percent more
reactive under conditions of sleep deprivation than in subjects who had
obtained a normal night of sleep,” Walker said. “It is almost as
though, without sleep, the brain reverts back to a more primitive
pattern of activity, becoming unable to put emotional experiences into
context and produce controlled, appropriate responses.”
As a result, that friendly, reasonable co-worker turns into what he
calls “emotional Jell-O” after an all-nighter, or else has to make a
Herculean effort to rein in those emotions.
“You can see it in the reaction of a military combatant soldier
dealing with a civilian, a tired mother to a meddlesome toddler, the
medical resident to a pushy patient,” says Walker. Next step: figuring
out how sleep deprivation cripples the emotional brain's connections to
the rational brain.