Contributed by Jonathan Darman and Arian Campo-Flores

When Judi Giuliani referred to her "big testosterone-factor husband" in the pages of Harper's Bazaar in February, her remarks were widely ridiculed and seen as evidence that the former New York mayor's new wife might not be quite ready for prime time. But after Louisiana Sen. David Vitter, Giuliani's top Southern conservative ally, admitted he'd solicited prostitutes from the famed "D.C. Madam," Judi's description seems remarkably apt. The testosterone factor may be at play, but not in quite the way his wife intended--and it could wind up as one of the biggest impediments to Giuliani's winning the GOP nomination for the White House.